Journal
TRENDS IN PARASITOLOGY
Volume 20, Issue 9, Pages 440-447Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2004.07.004
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Funding
- NIAID NIH HHS [R01 AI046919, 1R01 AI 52312-01, AI 46919-01A2, R01 AI052312] Funding Source: Medline
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Four Plasmodium species cause malaria in humans. Most malaria-endemic regions feature mixed infections involving two or more of these species. Factors contributing to heterogeneous parasite species and disease distribution include differences in genetic polymorphisms underlying parasite drug resistance and host susceptibility, mosquito vector ecology and transmission seasonality. It is suggested that unknown factors limit mixed Plasmodium species infections, and that mixed-species infections protect against severe Plasmodium falciparum malaria. Careful examination of methods used to detect these parasites and interpretation of individual- and population-based data are necessary to understand the influence of mixed Plasmodium species infections on malarial disease. This should ensure that deployment of future antimalarial vaccines and drugs will be conducted in a safe and timely manner.
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