Journal
NEUROSCIENCE LETTERS
Volume 367, Issue 2, Pages 181-185Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.05.113
Keywords
repetitive transcranial magnetic stimulation; motor sequence learning; motor cortex
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We investigated the effect of repetitive transcranial magnetic stimulation (rTMS) applied to the motor cortex, on the motor learning of sequential finger movements. Fifteen healthy subjects were trained to perform seven sequential finger movements of the left hand. Ten Hertz or sham rTMS with a testing motor threshold of 80% was applied to each subject during the task period. Stimulation with 10 Hz rTMS produced a better learning performance in terms of target score and execution time than sham stimulation. We conclude that high-frequency rTMS may modulate the excitability of the motor cortex and facilitate the sequential motor learning process in normal subjects. These findings may provide a basis for the development of therapeutic applications of rTMS in patients with impaired motor skill. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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