Journal
BRAIN RESEARCH
Volume 1019, Issue 1-2, Pages 289-292Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2004.06.011
Keywords
muscular dystrophy; Duchenne; synaptic plasticity
Categories
Ask authors/readers for more resources
The mdx (muscular dystrophy X-linked) mouse is a model for human Duchenne muscular dystrophy (DMD) and is characterized by the absence of the cytoskeletal protein dystrophin. Using a cerebellar slice preparation, we show that postsynaptically mediated long-term depression (LTD) is significantly reduced in mdx Purkinje cells, while presynaptically mediated paired-pulse facilitation (PPF) is normal. This disruption of LTD could contribute to the cognitive deficit in boys with Duchenne muscular dystrophy. Crown Copyright (C) 2004 Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available