Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 14, Issue 17, Pages 4405-4409Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.06.063
Keywords
3-hydroxyquinazoline-2,4-diones; antibacterial agents; bacterial topoisomerase inhibitors
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A series of 3 -hydroxyquinazoline-2,4-diones was synthesized and evaluated for antibacterial activity. This series represents a novel addition to the DNA gyrase inhibitor class of antibacterials. Appropriate substitutions onto the core template yielded compounds with excellent potency against E. coli gyrase and significant in vitro Gram-negative and Gram-positive antibacterial activity. (C) 2004 Elsevier Ltd. All rights reserved.
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