Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 200, Issue 5, Pages 623-635Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20041024
Keywords
STAT5A(1*6); leukemia; erythropoiesis; hematopoiesis; CD34
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Funding
- NCI NIH HHS [CA-09512, P01 CA059350, T32 CA009512, P01 CA 59350] Funding Source: Medline
- NHLBI NIH HHS [R01 HL 61401] Funding Source: Medline
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Activation of the transcription factor signal transducer and activator of transcription (STAT)5 is involved in various aspects of hematopoiesis, affecting cell proliferation, differentiation, and cell survival. Constitutive activation of STAT5 has also been associated with leukemic transformation. We overexpressed the constitutively active mutant STAT5A(1*6) in human cord blood CD34(+) cells and evaluated the effects on the hematopoietic potential of stem cells in a variety of in vitro and in vivo systems. The observed phenotypic changes were correlated with differential gene expression patterns induced by STAT5A(1*6). Our data indicate that a persistent activation of STAT5A in human hematopoietic stern and progenitor cells results in their enhanced self-renewal and diverts differentiation to the erythroid lineage.
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