Journal
SYNLETT
Volume -, Issue 11, Pages 1891-1896Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2004-831296
Keywords
aldehydes; aldol reactions; ketones; proline catalysis; water
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Proline-catalyzed aldol reactions between acetone or 4-thianone and different aldehydes are accelerated by addition of 110 equivalents of water to the reaction medium, allowing stoichiometric aldol reactions to proceed at acceptable rates.
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