Journal
MOLECULAR CELL
Volume 15, Issue 5, Pages 799-811Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2004.07.015
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DNA damage triggers multiple checkpoint pathways to arrest cell cycle progression. Less is known about the mechanisms that allow resumption of the cell cycle once checkpoint signaling is silenced. Here we show that while in undamaged cells several redundant pathways can promote the onset of mitosis, this redundancy is lost in cells recovering from a DNA damage-induced arrest. We demonstrate that Plk1 is crucial for mitotic entry following recovery from DNA damage. However, Plk1 is no longer required in cells depleted of Weel, and we could show that Plk1 is involved in the degradation of Weel at the onset of mitosis. Thus, our data show that the cell cycle machinery is reset in response to DNA damage and that cells become critically dependent on Plk1-mediated degradation of Weel for their recovery.
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