Journal
VIROLOGY
Volume 327, Issue 1, Pages 8-15Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2004.06.027
Keywords
chemokines; virus; innate immune response; cell trafficking; dendritic cell; T cell activation
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Funding
- PHS HHS [41249] Funding Source: Medline
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The role of CC chemokine ligand 3 (CCL3) in activation of dendritic cells (DCs) following mouse hepatitis vir-us (MHV) infection of the central nervous system (CNS) was examined. The results indicate that CCL3 participates in an effective host response to MHV infection by contributing to CD11c(+)CD11b(+)CD8alpha(-) DC maturation, activation, and migration to cervical lymph nodes (CLN). Diminished CD8alpha(-) DC activation correlated with reduced IFN-gamma expression by virus-specific T cells accompanied by increased IL-10 production suggesting that CCL3 contributes to an effective host response to viral infection by enhancing the T cell activation potential of DC. (C) 2004 Elsevier Inc. All rights reserved.
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