Journal
CANCER LETTERS
Volume 213, Issue 1, Pages 73-82Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.05.020
Keywords
vascular endothelial growth factor; microvessel density; survival; clinicopathological factor
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Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family of proangiogenic factors and its overexpression has been linked to pathological angiogenesis. We studied the relationship between the expression of PlGF and VEGF in human gastric cancer tissues and microvessel density (MVD), as well as clinical outcome in 79 patients with gastric cancer by using an enzyme immunoassay for PlGF and VEGF expression levels in gastric cancers and surrounding non-cancerous mucosa. PIGF protein levels were significantly higher in tumor than in the corresponding non-tumorous mucosa (median value 48.5 vs 9.8 pg/mg, P < 0.001). In contrast, VEGF protein levels were not (66.7 vs 80.7 pg/mg, P = 0.522). VEGF expression level was not significantly correlated with MVD, patient survival, and clinicopathological factors except Lauren classification in this study. PIGF may be an important angiogenic factor in human gastric cancer, and PIGF expression level was significantly correlated with serosal invasion, positive lymph node metastases, tumor stages, and patient survival. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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