Journal
JOURNAL OF IMMUNOLOGY
Volume 173, Issue 6, Pages 3647-3652Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.173.6.3647
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Funding
- NIAID NIH HHS [T32 AI07334-15, R01 AI 52116] Funding Source: Medline
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The maintenance of tolerance is likely to rely on the ability of a T cell to polarize surface molecules providing help to only specific APCs. The formation of a mature immunological synapse leads to concentration of the TCR at the APC interface. In this study, we show that the CD40-CD154 receptor-ligand pair is also highly concentrated into a central region of the synapse on mouse lymphocytes only after the formation of the TCR/CD3 c-SMAC. Concentration of this ligand was strictly dependent on TCR recognition, the binding of ICAM-1 to T cell integrins and the presence of an intact cytoskeleton in the T cells. This may provide a novel explanation for the specificity of T cell help directing the help signal to the site of Ag receptor signal. It may also serve as a site for these molecular aggregates to coassociate and/or internalize alongside other signaling receptors.
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