Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 190, Issue 6, Pages 1109-1118Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/423488
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Funding
- NIAAA NIH HHS [R01 AA 13215-01] Funding Source: Medline
- NIAID NIH HHS [R01 AI 34954] Funding Source: Medline
- NIDDK NIH HHS [R03 DK 54842-03] Funding Source: Medline
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Antioxidant enzymes, including heme oxygenase (HO)-1, are an important line of defense against oxidant-mediated liver injury. Because hepatitis C virus (HCV) infection appears to increase the production of oxidants, we evaluated levels of antioxidant enzymes and HO-1 in liver-biopsy samples from HCV-infected patients by immunoblot and semiquantitative reverse-transcriptase polymerase chain reaction. In HCV-infected liver samples, levels of immunoreactive HO-1 and HO-1 mRNA were >4-fold lower than levels in control samples, but levels of superoxide dismutase and catalase were unaffected. Immunohistochemical results confirmed the decreased expression of HO-1 in hepatocytes from liver samples from HCV-infected patients but not in those from patients with other chronic liver diseases. The expression of HO-1 was also reduced in cell lines that stably express HCV core protein, which suggests that core gene products are capable of regulating the expression of HO-1.
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