Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 131, Issue 3, Pages 263-268Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2004.06.001
Keywords
gyrification index; magnetic resonance imaging; prefrontal cortex; cerebral convolution; autistic disorder
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The gyrification index (GI), the ratio of total to outer cortical contour, was applied to measure the cerebral folding patterns in autism. GI was examined on a frontal coronal slice obtained from MRI scans of 30 nonmentally retarded individuals with autism and 32 matched healthy controls. In the autistic group, left frontal GI was higher in children and adolescents but not in adults. Cortical folding was decreased bilaterally with age in the total autistic sample but not in controls. These preliminary finding; suggest that the gyrification patterns in autism may be abnormal, which could be related to the various cortical anomalies observed in this disorder. (C) 2001 Elsevier Ireland Ltd. All rights reserved.
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