Journal
BIOCHEMICAL PHARMACOLOGY
Volume 68, Issue 6, Pages 1165-1170Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2004.03.048
Keywords
cell migration; cytokine; inflammation; stem cell; tissue damage; tissue regeneration
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Funding
- Telethon [GTF03008] Funding Source: Medline
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High mobility group box I (HMGB1) is a non-histone protein required to maintain chromatin architecture. Recent observations demonstrated that HMGB I can also act as a cytokine to regulate different biological processes such as inflammation, cell migration and metastasis. We showed previously that HMGB I can be released passively by cells that die in a traumatic and unprogrammed way, and can serve a signal of tissue damage. More recently, we showed that HMGB I can recruit stem cells: HMGB1 induces stem cell transmigration through an endothelial barrier; moreover, when beads containing HMGB I are implanted into healthy muscle, they recruit stem cells injected into the general circulation. The inflammatory and tissue-regenerating roles of HMGB I may be strictly interconnected, and are discussed here. (C) 2004 Elsevier Inc. All rights reserved.
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