Journal
NEUROREPORT
Volume 15, Issue 13, Pages 2123-2127Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200409150-00025
Keywords
anticipation; decision-making; fMRI; harm avoidance; nucleus accumbens; reward; risk-taking
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Funding
- NIDA NIH HHS [R01DA016663, R21DA13186, R01DA15392] Funding Source: Medline
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This study implemented a risk-taking task during fMIRI to probe the brain circuitry involved in risk-taking decision-making in 12 healthy control subjects. Partially supporting the initial hypotheses, deliberation prior to selection of safe relative to risky responses generated greater activation in the inferior frontal cortex, superior temporal gyrus, and middle temporal gyrus; and deliberation prior to selection of risky relative to safe responses generated greater activation in medial frontal cortex, occipital cortex, nucleus accumbens and caudate. Additionally, accumbens activation correlated positively with the harm avoidance subscale of the Temperament and Character Inventory (TCI) 125. These findings may provide target neural systems to study in subjects who exhibit problematic risk-taking behaviors and may partially explain why certain risky behaviors occur.
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