Synthesis and structure-activity relationships of the halovirs, antiviral natural products from a marine-derived fungus

The halovirs are linear, lipophilic peptides produced by a marine-derived fungus of the genus Seytalidium. We recently reported that these molecules possess potent in vitro activity against the herpes simplex viruses I and 2. Here we present structure-activity relationships defining key structural elements for optimal viral inhibition. Results demonstrate that an N-alpha-acyl chain of at least 14 carbons and an Aib-Pro dipeptide are critical for maintaining the antiviral activity. (C) 2004 Elsevier Ltd. All rights reserved.