Journal
TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume 199, Issue 3, Pages 316-331Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2004.01.018
Keywords
cytochrome P450; oxidative stress; hydrogen peroxide; superoxide anion radical; lipid peroxidation; reactive oxygen species; uncoupling; review
Categories
Funding
- NIDDK NIH HHS [R01 DK54812] Funding Source: Medline
Ask authors/readers for more resources
Mammalian cytochromes P450 (P450) are a family of heme-thiolate enzymes involved in the oxidative metabolism of a variety of endogenous and exogenous lipophilic compounds. Poor coupling of the P450 catalytic cycle results in continuous production of reactive oxygen species (ROS), which affects signaling pathways and other cellular functions. P450 generation of ROS is tightly controlled by regulation of gene transcription as well as by modulation of interactions between protein constituents of the monooxygenase that affects its activity, coupling, and stability. Malfunction of these mechanisms may result in a burst of ROS production, which can cause lipid peroxidation and oxidative stress. In turn, oxidative stress downregulates P450 levels by a variety of feedback mechanisms. This review provides an overview of recent advances in our understanding of these feedback mechanisms that serve to limit P450 production of ROS. Some of the more likely physiological and cellular effects of P450 generation of ROS are also discussed. (C) 2004 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available