Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 279, Issue 38, Pages 39289-39295Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M405793200
Keywords
-
Categories
Funding
- NIGMS NIH HHS [GM19014, GM31819, GM32833] Funding Source: Medline
Ask authors/readers for more resources
Claspin is an essential protein for the ATR-dependent activation of the DNA replication checkpoint response in Xenopus and human cells. Here we describe the purification and characterization of human Claspin. The protein has a ring-like structure and binds with high affinity to branched DNA molecules. These findings suggest that Claspin may be a component of the replication ensemble and plays a role in the replication checkpoint by directly associating with replication forks and with the various branched DNA structures likely to form at stalled replication forks because of DNA damage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available