Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 69, Issue 19, Pages 6329-6334Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo049405i
Keywords
-
Categories
Ask authors/readers for more resources
The efficient synthesis of optically active trisubstituted 1,2-ethylenediamines is described. Addition of aryl and/or alkyl Grignard reagents to a-amino N-diphenylphosphinoyl ketimines derived from a-amino acids was demonstrated to afford the desired trisubstituted 1,2-ethylenediamines in good yields and with high diastereoselectivities. Subsequent removal of the diphenyphosphinoyl group from the adduct was smoothly accomplished in reasonable yield without racemization under newly developed reductive conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available