Journal
SCIENCE
Volume 305, Issue 5691, Pages 1736-1739Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1092556
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Funding
- NIA NIH HHS [AG13499, AG14751, AG17265, AG05142] Funding Source: Medline
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Most explanations of the increase in life expectancy at older ages over history emphasize the importance of medical and public health factors of a particular historical period. We propose that the reduction in lifetime exposure to infectious diseases and other sources of inflammation-a cohort mechanism-has also made an important contribution to the historical decline in old-age mortality. Analysis of birth cohorts across the life-span since 1751 in Sweden reveals strong associations between early-age mortality and subsequent mortality in the same cohorts. We propose that a cohort morbidity phenotype represents inflammatory processes that persist from early age into adult life.
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