4.4 Article

Access to enantiopure polycyclic β-lactams by Diels-Alder reaction of novel inner-outer-ring 2-(silyloxy)dienes with a carbacepham skeleton

Journal

TETRAHEDRON LETTERS
Volume 45, Issue 39, Pages 7255-7259

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.08.022

Keywords

beta-lactam; 2-azetidinone; carbacepham; diene; Diels-Alder cycloaddition

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The synthesis of unprecedented inner-outer-ring 2-[tert-butyidimethylsilyloxy]dienes with a carbacepham structure in optically pure form and their totally pi-facial endo selective Diels-Alder reactions to structurally novel polycyclic beta-lactams is reported. (C) 2004 Published by Elsevier Ltd.

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