4.5 Article

Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: Metabolism-directed optimization studies towards orally bioavailable derivatives

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 14, Issue 18, Pages 4615-4621

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.07.009

Keywords

PDE7; phosphodiesterase; ADME; cAMP

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The synthesis and optimization of pharmacokinetic parameters of structurally novel small PDE7 inhibitors is discussed. (C) 2004 Elsevier Ltd. All rights reserved.

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