Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 56, Issue 11, Pages 1621-1633Publisher
ELSEVIER
DOI: 10.1016/j.addr.2004.05.002
Keywords
microfabrication; nanofabrication; biodegradable polymer; drug delivery
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This paper presents state-of-the-art micro and nano-fabrication techniques for biodegradable polymers. Replication molding, using a rigid or elastic master, can pattern structures on a polymer surface in a submicron resolution at a low cost. Layer-bylayer rapid prototyping methods are promising in producing controlled release units with complicated geometries, release mechanisms and the ability to control microstructure and composition. Special attention is paid to the fast, flexible, and non-invasive laser fabrication techniques that have great potential in the fabrication of biodegradable polymer drug delivery devices in both a laboratory and industry scale. (C) 2004 Elsevier B.V. All rights reserved.
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