Journal
FEBS LETTERS
Volume 575, Issue 1-3, Pages 91-94Publisher
WILEY
DOI: 10.1016/j.febslet.2004.08.039
Keywords
malaria; artemisinin; chloroquine; carbon monoxide; oxidative stress; P. falciparum
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The role of haem iron (II) and oxidative stress in the activation and antimalarial activity of artemisinin is unclear. Thus, we submitted malaria parasite to modified culture conditions: artemisinin activity increased by 20-30% under an oxygen-rich atmosphere (20% O-2 instead of standard 1% O-2), and by 40-50% in the presence of carboxy-haemoglobin, and 2% carbon monoxide, conditions which inhibit haem iron (II) reactivity. In all cases, parasite growth and chloroquine activity were unaffected. We conclude that in the malaria parasite arternisinin is not activated by haem iron and that free radicals are not needed for its toxicity. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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