Journal
BRAIN RESEARCH
Volume 1021, Issue 2, Pages 277-280Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2004.05.072
Keywords
circadian; calcium; retina; phototransduction
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Funding
- NEI NIH HHS [F32 EY013920-01, F32 EY013920-02, F32 EY013920-03] Funding Source: Medline
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Circadian oscillators of chicken retinal cone photoreceptors modulate the gating properties of cGMP-gated channels (CNGCs) such that they have a higher apparent affinity for cGMP during the subjective night. This effect is driven in part by cAMP, which acts through Erk MAP kinase to initiate a cascade leading to modulation of CGNCs. Here, we show that CAMP effects on the gating properties CNGCs persist when protein synthesis is blocked. The effects is cAMP also persist when calcium influx through L-type channels is blocked by nitrendipine. The mechanisms whereby cAMP modulates CNGCs therefore differ from those previously reported to underline regulation of melatonin synthesis and secretion. (C) 2004 Elsevier B.V. All rights reserved.
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