Journal
AIDS
Volume 18, Issue 14, Pages 1958-1961Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002030-200409240-00014
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One likely mechanism of virological failure is poor antiretroviral. drug diffusion in sites of viral replication such as the genital tract. We measured antiretroviral drug concentrations in blood and semen in 13 HIV-infected men failing treatment. Enfuvirtide did not cross the blood-testis barrier, whereas tenofovir accumulated in semen. Unlike indinavir, semen concentrations of lopinavir, amprenavir, saquinavir and efavirenz were ineffective. These are worrying findings, because suboptimal semen drug concentrations may enhance the risk of sexually transmitted drug-resistant HIV variants.
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