Journal
NEUROLOGY
Volume 63, Issue 6, Pages 1079-1080Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.WNL.0000138572.82125.F5
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Oral prednisone (1)might be a convenient, inexpensive alternative to IV methylprednisolone ( IVMP) if the bioequivalent dose was known. We compared the total amount of steroid absorbed after 1250 mg oral prednisone vs 1 gram IVMP in 16 patients with multiple sclerosis (MS). At 24 hours, the mean area under the concentration-time curve (AUC), the main component of bioavailability, did not differ between groups (p=0.122). This suggests that the amount of absorbed corticosteroid is similar after either steroid at these doses.
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