Journal
APPLIED PHYSICS LETTERS
Volume 105, Issue 14, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.4897630
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Funding
- National Science Foundation [ECCS-0846961]
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Thyroglobulin (Tg) is a sensitive indicator of persistent or recurrent differentiated thyroid cancer of follicular cell origin. Detection of Tg in human serum is challenging as bio-receptors, such as anti-Tg, used in immunoassay have relatively weak binding affinity. We engineer sensing surfaces using the competitive adsorption of proteins, termed the Vroman Effect. Coupled with Surface Plasmon Resonance, the cross-responsive interactions of Tg on the engineered surfaces produce uniquely distinguishable multiple signature patterns, which are discriminated using Linear Discriminant Analysis. Tg-spiked samples, down to 2 ng/ml Tg in undiluted human serum, are sensitively and selectively discriminated from the control (undiluted human serum). (C) 2014 AIP Publishing LLC.
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