Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 138, Issue 1-2, Pages 207-216Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2004.04.019
Keywords
deep brain stimulation; electrodes; stainless-steel; platinum-iridium; fluoro-jade; neuronal damage; image analysis
Categories
Ask authors/readers for more resources
High-frequency stimulation (HFS) of deep brain structures is a powerful therapeutic tool for the treatment of various movement disorders in patients. However, the pathophysiological mechanisms of this therapeutic approach on basal ganglia network function are still largely unknown. Hitherto, experimental studies have focused on short-term stimulation. Since patients receive HFS for many years, animal studies which reproduce the conditions of long-term stimulation will be necessary to accurately investigate the effects of HFS. However, stimulation parameters of acute HFS cannot be easily transferred to long-term conditions. Accordingly, for this purpose we studied the influence of different charge densities (0, 3, 6.5, 13 and 26 muC/cm(2)/phase) and duration (4h or 3 days) of subthalamic nucleus (STN)-HFS using stainless-steel and platinum-iridium (Pt/Ir) electrodes on neuronal tissue damage in rats. Our data demonstrate the advantage of Pt/Ir over stainless-steel electrodes when used in short-term HFS (frequency 130 Hz, pulse width 60 mus) and indicate that HFS using Pt/Ir-electrodes pulsed with 3 muC/cm(2)/phase over 3 days did not produce any relevant tissue damage in the STN. (C) 2004 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available