4.8 Article

Efficient preparation of glycoclusters from silsesquioxanes

Journal

ORGANIC LETTERS
Volume 6, Issue 20, Pages 3457-3460

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol040043a

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Funding

  1. NIDDK NIH HHS [R01 DK 009700] Funding Source: Medline

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A new type of glycocluster based on polyhedral oligosilsesquioxanes (POSS) has been efficiently prepared from unprotected mannoside and lactoside employing a convergent approach of thiol-radical addition reaction. The versatility of this approach was demonstrated by functionalization of mannosides and lactosides of different-length spacers.

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