Journal
JOURNAL OF CONTROLLED RELEASE
Volume 99, Issue 2, Pages 231-240Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2004.06.020
Keywords
supercritical fluids; controlled release; cholesterol; PMMA; poly(epsilon-caprolactone)
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Poly(methyl methacrylate), PMMA, and of PMMA/Poly(epsilon-caprolactone), PCL, microspheres were loaded with different amounts of cholesterol by using a supercritical carbon dioxide (SC-CO2) impregnation process in order to use a clean technique with the absence of organic solvents, and to provide information for the infusion of additives into nonporous polymeric substrates. A conventional dissolution-evaporation method was also used to obtain PMMA and PMMA-PCL microparticles loaded with cholesterol. The obtained microspheres were characterized by environmental scanning electronic microscope, ESEM, nuclear magnetic resonance spectroscopy, NMR, and differential scanning calorimetry, DSC, thermal analysis. A comparison of drug release from particles obtained using both methods, the supercritical and the conventional, is presented. (C) 2004 Elsevier B.V. All rights reserved.
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