Journal
CANCER LETTERS
Volume 213, Issue 2, Pages 165-172Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2003.12.028
Keywords
folate receptor targeting; liposomal drug delivery; tumor macrophages; ovarian cancer therapy
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Funding
- NCI NIH HHS [CA 08298, CA 89581] Funding Source: Medline
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The folate receptor (FR) is overexpressed on many epithelial cancers and has been exploited for targeted delivery of folate-linked liposomes to cancer cells in vitro. The present studies investigate the distribution of folate-targeted liposomes in a FR(+) mouse model of ovarian cancer. According to flow cytometric analysis, folate-conjugation of liposomes significantly enhanced their uptake into ovarian cancer cells and tumor-associated macrophages within tumor ascites fluid. Compared to ovarian cancer cells, macrophages acquired tenfold more liposomes, and approximately 50% of this uptake was FR-dependent. These results demonstrate that, in addition to their cancer cell-targeting properties, folate-liposomes may be useful for targeting drugs to tumor-associated macrophages in vivo. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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