Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 12, Issue 19, Pages 5019-5030Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.06.018
Keywords
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Funding
- NIDA NIH HHS [DA08590, DA015700, DA016478] Funding Source: Medline
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Cocaine abuse continues to be prevalent and effective therapies for cocaine craving and addiction remain elusive. In the last decade immunopharmacotherapy has been proposed as a promising means to alleviate this illness. By using the organism's natural immune response, an anti-cocaine vaccine promotes the production of cocaine-specific antibodies that sequester the drug before their passage into the brain, where it exerts its reinforcing and thus addictive effects. A series of studies demonstrating the cocame-blocking properties of various immunogenic conjugates will be reviewed in the context of the neuropsychopharmacological profile of the drug. (C) 2004 Elsevier Ltd. All rights reserved.
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