Journal
SEMINARS IN CANCER BIOLOGY
Volume 14, Issue 5, Pages 357-364Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2004.04.015
Keywords
notch; Hes1; lung development; lung cancer; Mash1
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Funding
- NCI NIH HHS [R01-CA70244] Funding Source: Medline
- NIDDK NIH HHS [DK07751] Funding Source: Medline
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Although data regarding the role of the Notch pathway in human lung cancer are still limited, fetal lung developmental studies suggest that Notch signaling plays a critical role in regulating airway epithelial development. The moderate hypotrophic phenotype of lungs from animals bearing a Hes1 mutation, and the expression of Notch components in the distal lung bud during branching morphogenesis, together suggest that Notch may play a role in normal lung growth, especially in Clara cell precursors. Non-small cell lung cancers, including adenocarcinoma, appear to actively utilize this conserved developmental pathway. Pharmacologic inhibition of the Notch pathway is a potential experimental approach to lung cancer treatment. (C) 2004 Elsevier Ltd. All rights reserved.
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