Journal
TRENDS IN NEUROSCIENCES
Volume 27, Issue 10, Pages 579-582Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2004.07.006
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Funding
- NIGMS NIH HHS [R01 GM059781] Funding Source: Medline
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A genetic screen for resistance to ethanol intoxication in Caenorhabditis elegans isolated mutants of the gene slo-1. slo-1 encodes the pore-forming subunit of a large-conductance Ca2+-activated K+ channel previously shown to limit excitatory neurotransmitter release in C. elegans. Electrophysiological data recorded in vivo are consistent with a model in which ethanol potentiation of SLO-1 produces intoxication in C. elegans by reducing excitatory neurotransmitter release.
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