Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 48, Issue 10, Pages 3989-3995Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.10.3989-3995.2004
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Funding
- NIAID NIH HHS [R01 AI048769, AI42869, AI48769] Funding Source: Medline
- NIEHS NIH HHS [P30 ES00210, P30 ES000210] Funding Source: Medline
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Many strains of Chlamydia suis, a pathogen of pigs, express a stable tetracycline resistance phenotype. We demonstrate that this resistance pattern is associated with a resistance gene, tet(C), in the chlamydial chromosome. Four related genomic islands were identified in seven tetracycline-resistant C. suis strains. All resistant isolates carry the structural gene tet(C) and the tetracycline repressor gene tetR(C). The islands share significant nucleotide sequence identity with resistance plasmids carried by a variety of different bacterial species. Three of the four tet(C) islands also carry a novel insertion sequence that is homologous to the IS605 family of insertion sequences. In each strain, the resistance gene and associated sequences are recombined into an identical position in a gene homologous to the inv gene of the yersiniae. These genomic islands represent the first examples of horizontally acquired DNA integrated into a natural isolate of chlamydiae or within any other obligate intracellular bacterium.
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