Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 61, Issue 19-20, Pages 2437-2445Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-004-4194-9
Keywords
Cys-tRNA(Cys); cysteine biosynthesis; cysteinyl-tRNA synthetase; archaea; methanogens
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Aminoacyl-tRNA ( transfer RNA) synthetases are essential components of the cellular translation machinery as they provide the ribosome with aminoacyl-tRNAs. Aminoacyl-tRNA synthesis is generally well understood. However, the mechanism of Cys-tRNACys formation in three methanogenic archaea (Methanocaldococcus jannaschii, Methanothermobacter thermautotrophicus and Methanopyrus kandleri) is still unknown, since no recognizable gene for a canonical cysteinyl-tRNA synthetase could be identified in the genome sequences of these organisms. Here we review the different routes recently proposed for Cys-tRNA(Cys) formation and discuss its possible link with cysteine biosynthesis in these methanogenic archaea.
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