Journal
MOVEMENT DISORDERS
Volume 19, Issue 10, Pages 1256-1258Publisher
WILEY-LISS
DOI: 10.1002/mds.20194
Keywords
amantadine; levodopa-induced dyskinesias; GTP cyclohydrolase I deficiency
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Amantadine suppressed severe levodopa-induced choreic dyskinesia, which developed at initiation of levodopa therapy, in two siblings manifesting dystonia with motor delay phenotype of GTP cyclohydrolase 1 deficiency caused by compound heterozygous GCH1 mutations. Our finding suggests a beneficial effect of amantadine on this type of dyskinesia frequently observed in relatively severe dopamine-deficient metabolic disorders. (C) 2004 Movement Disorder Society.
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