Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 5, Issue 10, Pages 848-854Publisher
NATURE RESEARCH
DOI: 10.1038/nrm1495
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Funding
- NIGMS NIH HHS [R01 GM057233] Funding Source: Medline
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After 40 years of searching for the eukaryotic replicator sequence, it is time to abandon the concept of 'the' replicator as a single genetic entity. Here I propose a 'relaxed replicon model' in which a positive initiator-replicator interaction is facilitated by a combination of several complex features of chromatin. An important question for the future is whether the positions of replication origins are simply a passive result of local chromatin structure or are actively localized to coordinate replication with other chromosomal activities.
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