Journal
JOURNAL OF LIPID RESEARCH
Volume 45, Issue 10, Pages 1793-1805Publisher
ELSEVIER
DOI: 10.1194/jlr.R400006-JLR200
Keywords
systems biology; transgenic mice; quantitative trait locus mapping; principal components; Bayesian networks; correlation coefficients; genetics; genomics; proteomics
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The goal of systems biology is to define all of the elements present in a given system and to create an interaction network between these components so that the behavior of the system, as a whole and in parts, can be explained under specified conditions. The elements constituting the network that influences the development of atherosclerosis could be genes, pathways, transcript levels, proteins, or physiologic traits. jlr In this review, we discuss how the integration of genetics and technologies such as transcriptomics and proteomics, combined with mathematical modeling, may lead to an understanding of such networks. -Ghazalpour, A., S. Doss, X. Yang, J. Aten, E. M. Toomey, A. Van Nas, S. Wang, T. A. Drake, and A. J. Lusis. Toward a biological network for atherosclerosis.
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