Journal
JOURNAL OF BIOLOGICAL RHYTHMS
Volume 19, Issue 5, Pages 361-373Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0748730404268111
Keywords
circadian rhythms; posttranscriptional regulation; posttranslational regulation; phosphorylation; kinases; phosphatases
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Circadian rhythms have been observed in diverse organisms, including plants, animals, bacteria, and fungi. In such organisms, the circadian clock is primarily composed of a cell-autonomous transcriptional feedback loop. In addition to transcriptional regulation, the modification of core clock transcripts and proteins can dramatically affect the circadian clock. In this review, the authors discuss some of the posttranscriptional and posttranslational modifications and their effects on the circadian clock. The combined outcome of these modifications is to adjust the timing of the clock to produce a circadian oscillator that takes approximately 24 h.
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