Journal
CLINICAL IMMUNOLOGY
Volume 113, Issue 1, Pages 4-13Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2004.05.001
Keywords
systemic lupus erythematosus; T cell; human; autoimmune
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Funding
- NIAMS NIH HHS [AR48055, AR43308] Funding Source: Medline
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Recent studies in patients with systemic lupus erythematosus (SLE) have demonstrated that autoantigen-reactive T cells can be isolated from peripheral blood and that such cells can support autoantibody production ex vivo, suggesting that they may have a central role in the pathogenesis of disease. In addition, recent work has identified and characterized signaling abnormalities in T cells from SLE that may be fundamental to the disease. This review will examine the role of T cells in the pathogenesis of SLE and it will consider pathogenic mechanisms by which T cells escape normal of immunological tolerance. The focus will be on recent studies characterizing autoantigen-reactive human T cells and signaling abnormalities identified in T cells from patients with SLE. Published by Elsevier Inc.
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