Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 191, Issue 4, Pages 1173-1182Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2004.04.015
Keywords
endocervical adenocarcinoma of uterus; comparative genomic hybridization (CGH); array-based CGH; copy number abnormality; metastasis
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Objectives: This study aimed to estimate the gene loci associated with carcinogenesis of endocervical adenocarcinoma of uterus (EA) and metastasis. Study design: Sixteen patients with EA were studied; 6 had nodal metastasis. DNA was extracted from EAs, and subjected to both conventional comparative genomic hybridization (CGH) and array-based CGH. Copy number abnormalities were compared between cases with and without nodal metastasis. Results: In all EAs, high. frequencies of copy number losses were detected in genes LRP1B (on 2q2l.2), DAB2 (5p13), and DCC (18q21.3), as well as regions 3p, 16q, and 22q, and copy number amplifications in genes NRAS (1p13.2), TOP2A (17q21-q22), NCOA3(AIB1) (20q12), and ARSA (22q tel). Nodal metastasis was associated with high frequencies of copy number loss in genes PGRMC2 and LAMA3 and amplification in CDK6 and NCOA3(AIB1). Conclusion: This is the first report of gene copy number alterations spanning the whole genome in EA. These altered genes are speculated to be associated with EAs as a tumor suppressor and/or oncogene. (C) 2004 Elsevier Inc. All rights reserved.
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