Journal
BLOOD
Volume 104, Issue 7, Pages 2010-2019Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2003-12-4219
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Funding
- NCRR NIH HHS [RR04050] Funding Source: Medline
- NIAID NIH HHS [R01 AI42384, R01 AI446723, R01 AI49165] Funding Source: Medline
- NIDDK NIH HHS [DK63443, DK5493, R01 DK98183] Funding Source: Medline
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Circulating endothelial progenitors contribute to neovascularization at sites of injury and tumorigenesis in postnatal life. Yet, the molecular mechanisms initiating the endothelial developmental program of these precursors remain elusive. Here we provide evidence that endothelial development from progenitors circulating in human cord blood requires angiopoietins, a set of growth factors also involved in vascular branching during embryogenesis. We show that cord blood cells with the potential for endothelial development reside in a CD34(+)CD11b(+) subset capable of autonomously producing and binding angiopoietins. Functionally, endogenous angiopoietin-1 regulates initial endothelial cell commitment, whereas angiopoietin-2 enhances expansion of the endothelial cell progeny. These findings suggest a role for angiopoietins as regulators of endothelial development from circulating progenitors and imply a function of angiopoietins at distinct developmental steps in postnatal angiogenesis. (C) 2004 by The American Society of Hematology.
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