Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 27, Issue 10, Pages 1626-1629Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.27.1626
Keywords
propranolol; hydroxypropylmethyleellulose (HPMC); dissolution test; response surface methodology
Categories
Ask authors/readers for more resources
The purpose of this study was to develop propranolol extended release formulations containing hydroxypropylmethylcellulose (HPMC). The results indicate that the drug release from the tablet form containing a high amount of HPMC was incomplete, and avicel addition could increase the release percent at a later stage. In order to readily obtain an optimal formulation, response surface methodology and multiple response optimization utilizing a quadratic polynomial equation was used. The model formulations were prepared according to a factorial design. The effects of causal factors including the HPMC/drug ratio (X-1) and avicel level (X-2), on drug release were also measured. The drug release percentage at 1.5, 4, 8, 14 and 24 It were the target response and were restricted to not more than 25%, 35-50%, 55-70%, 75-90%, and 95-110%, respectively. The results showed that the optimized formulation provided a dissolution pattern equivalent to the predicted curve, which indicated that the optimal formulation could be obtained using response surface methodology. The mechanism of drug release from HMPC matrices tablets followed quasi-Fickian diffusion.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available