Journal
CONTROLLED CLINICAL TRIALS
Volume 25, Issue 5, Pages 493-501Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cct.2004.07.005
Keywords
clinical trial design; cross-over design; parallel design; phase II study
Funding
- NCI NIH HHS [CA49764-15] Funding Source: Medline
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In this note, we outline the benefits of a partial cross-over design for a class of experiments where the interest is the cumulative effect of dose versus placebo. The goal of our design strategy is to answer several complex question efficiently in a phase II setting with a minimal number of assumptions with an eye towards planning a phase III study. (C) 2004 Elsevier Inc. All rights reserved.
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