Journal
BEHAVIORAL NEUROSCIENCE
Volume 118, Issue 5, Pages 1052-1061Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.118.5.1052
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Funding
- NIMH NIH HHS [MH 52384, MH 57250, MH 59906, MH 12907, MH 62044, MH 47840] Funding Source: Medline
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The authors investigated whether corticotropin-releasing factor (CRF) within the central nucleus of the amygdala (CeA) and bed nucleus of the stria terminalis (BNST) is a critical component of the neural circuitry mediating conditioned defeat. In this model, hamsters that have experienced social defeat subsequently display only submissive-defensive agonistic behavior instead of territorial aggression. Conditioned defeat was significantly reduced following infusion of the CRF receptor antagonist D-Phe CRF((12-41)) into the BNST but not into the CeA. In another experiment, hamsters given unilateral lesions of the CeA and infusions of D-Phe CRF((12-41)) into the contralateral BNST displayed significantly less submissive behavior than did controls. These data suggest that CRF acts within a neural circuit that includes the amygdala and the BNST to modulate agonistic behavior following social defeat.
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