Journal
ARTHRITIS AND RHEUMATISM
Volume 50, Issue 10, Pages 3329-3333Publisher
WILEY-LISS
DOI: 10.1002/art.20494
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Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome is a severe inflammatory disease that recently was associated with mutations in CIAS1. It was hypothesized that these mutations may lead to enhanced inflammatory responses. Herein, we provide evidence that inflammation in the CINCA syndrome is characterized by enhanced interleukin-1beta (IL-1beta) and IL-18 release upon stimulation of blood cells and show that this release is caspase I dependent.
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