Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 68, Issue 10, Pages 2091-2095Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.68.2091
Keywords
casein phosphopeptide; human cell line; mitogenic effect; IgA-enhancing effect; interleukin-6
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The effect of bovine beta-casein (1-28) purified from commercial casein phosphopeptide preparations on human T, B, and monocyte cell lines was evaluated. Beta-casein (1-28) enhanced the proliferation of the following: T cell lines HUT-78, Jurkat Clone E6-1, and MOLT-4; B cell lines BALL, KHM-1B, and U266B1; and monocyte cell lines U937 and HL-60. Moreover, beta-casein (1-28) stimulated IgA production by KHM-1B over 96 h of culture. Semi-quantitative reverse transcriptional-polymerase chain reaction analysis indicated that beta-casein (1-28) enhanced mRNA expression of interleukin (IL)-6 in U266B1 and KHM-1B. These results suggest that beta-casein (1-28) exerts a mitogenic effect on human T, B, and monocyte cells, and an IgA-enhancing effect on B cells.
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