Journal
CHIRURG
Volume 75, Issue 10, Pages 988-995Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00104-004-0847-3
Keywords
MRSA infections; methicillin-resistant; Staphylococcus aureus; gentamicin-vancomycin PMMA beads; antibiotic release
Categories
Ask authors/readers for more resources
Introduction. We present gentamicin-van-comycin-impregnated beads that can be produced intraoperatively in moulds and demonstrated their successful use in ten cases of problematic Methicillin-resistent Staphylococcus aureus (MRSA) infection. Methods. To produce the antibiotically loaded PMMA beads, a two-part mould of polyoxymethylene was used. The mixture of PMMA and antibiotic is poured into the mould halves, and during polymerisation the halves bond together. The in vivo antibiotic concentrations of wound secretion from the redon drainage were measured by fluorescence-polarisation immunoassay, and a concentration/time function was determined. The PMMA beads (2 g of vancomycin plus 0.5 g of gentamicin plus 40 g of PMMA) were implanted in ten patients aged 41-76 years. Results. In all ten patients, the infection was cured (follow-up 15 months). Conclusion. The combination of gentamicin and vancomycin in the PMMA of standardised beads represents a good alternative in the treatment of MRSA infections. Understanding of the mechanism of antibiotic release from PMMA allows differentiated dosing during systemic application.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available