Journal
LEUKEMIA
Volume 18, Issue 10, Pages 1711-1716Publisher
SPRINGERNATURE
DOI: 10.1038/sj.leu.2403443
Keywords
hepatitis C virus; marginal zone lymphoma; splenic lymphoma with villous lymphocytes; interferon; ribavirin; large granular lymphocyte leukemia
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A link between chronic hepatitis C virus (HCV) infection and low-grade B-cell lymphomas has been suggested by epidemiological studies. Marginal zone lymphomas (MZLs) including splenic lymphomas with villous lymphocytes are among the most frequently reported subgroups in the setting of chronic HCV infection. In this study, we examined the effect of antiviral treatment in eight patients with HCV-associated MZL. We found that five out of eight patients have responded to interferon alpha and ribavirin. In some cases, hematologic responses were correlated to virologic responses. In addition, we report a case of large granular lymphocyte leukemia occurring in association with MZL and HCV, and responding to interferon and ribavirin. We suggest that there is an etiologic link between HCV and antigen-driven lymphoproliferative disorders.
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